Phipatanakul reports personal fees from GSK, Genentech, Novartis, Regeneron, Sanofi, and Teva, grants from Genentech, Novartis, Regeneron, Sanofia, Circassia, Monaghen, Thermo Fisher, Alk Abello, Lincoln Diagnostics, GSK, Kaleo, and Merck, grants from Genentech, Regeneron, Novartis, and the US NIH, outside the submitted work. Bacharier has nothing to disclose.Ĭonflict of interest: Dr. Forno has nothing to disclose.Ĭonflict of interest: Dr. Han has nothing to disclose.Ĭonflict of interest: Dr. Gaietto has nothing to disclose.Ĭonflict of interest: Dr.
MICHAEL GAIETTO FACEBOOF PDF
Please open or download the PDF to view this article.Ĭonflict of interest: Dr. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. It is published here in its accepted form prior to copyediting and typesetting by our production team. This manuscript has recently been accepted for publication in the European Respiratory Journal. Our findings suggest that violence-related distress may worsen lung function and quality of life in youth with asthma (even those treated with low-dose inhaled corticosteroids) and further support policies to reduce exposure to violence among children in the U.S. Similar findings for FEV 1 and FVC were obtained in the prospective study of Puerto Rican youth. In a multivariable analysis in VDKA, each 1-point increment in the CCDS score was associated with decrements of 3.27% in %predFEV 1 (95% confidence interval =−6.44% to −0.22%, p=0.04) and a 2.65% decrement in percent predicted FVC (95% CI=−4.86% to −0.45%, p=0.02), and 0.30 points in the overall PAQLQ score (95% CI=−0.50 to −0.10, p<0.01). Our outcomes of interest were percent predicted (%pred) lung function measures and (in VDKA only) asthma control (assessed using the Asthma Control Test) and asthma-related quality of life (assessed using the Pediatric Asthma Quality of Life questionnaire). Violence-related distress was assessed using the Checklist of Children's Distress Symptoms (CCDS) scale. We then replicated our findings for lung function in a prospective study of 232 Puerto Rican youth followed for an average of 5♴ years.
MICHAEL GAIETTO FACEBOOF TRIAL
We examined whether increasing violence-related distress over time is associated with worse lung function and worse asthma control or quality of life in a secondary analysis of a 48-week randomized clinical trial in 98 youth with asthma (ages 9–16 years) treated with low-dose inhaled corticosteroids (the Vitamin D Kids Asthma Study ). Increasing violence-related distress over time was associated with worse lung function and worse asthma-related quality of life in youth with asthma despite treatment with low-dose inhaled corticosteroids.Įxposure to violence has been associated with lower lung function in cross-sectional studies.
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